GNAT3 and Alzheimer disease: A disturbed cholesterol and lipid metabolism in the brain has long been suspected in AD.55 In particular, growing evidence suggests a link between increased blood levels of specific bile acids, including GDCA, and AD.7, 56 Considering the multiple roles of bile acids and their modulation by diet, exercise, and gut microbiota, their comprehensive profiling in future studies on CD would certainly be informative.