The serum IGFBP‐3 levels were 4.63 (3.79, 6.63) μg/mL, 4.59 (3.5, 5.03) μg/mL, and 2.42 (1.90, 3.20) μg/mL in the different groups of CRC patients with well differentiation, moderate differentiation, and poor differentiation, respectively. This evidence concerns the gene IGFBP3 and colorectal carcinoma.