Using the same control subjects and patients from Fig. 2, We found that the localisation of pericentrin was markedly altered in NM patient myonuclei (Fig. 5a–d; note the rim of pericentrin around the nuclear surface, as well as nearby bright puncta in control subjects; note the increased accumulation of pericentrin immunolabelling at the nuclear surface in patients). Here, PCNT is linked to nemaline myopathy.