ERBB2 and breast carcinoma: For example, combined knockdown of two of the polarity regulators Scribble, Dlg1 or AF-6 or knockdown of one of these polarity regulators in combination with ErbB2 activity [98] as well as knockdown of Par3 in combination with ErbB2 activity [99] leads to loss of epithelial polarity and induces invasion of breast cancer cells without inducing EMT.