Binding and stimulation of the receptor for advanced glycation end products (RAGE) by protein-bound CML (PB-CML), protein-bound CEL (PB-CEL), and MG-H1 can increase oxidative stress and upregulate transcription of NF-κB-dependent genes, i.e., inflammatory genes [10–12]. Here, NFKB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.