TGFB1 and renal fibrosis: Furthermore, the downregulation of miR-30e is associated with TGF-β1-mediated epithelial–mesenchymal transition (EMT) and kidney fibrosis [19], while the overexpression of miR-30e could promote the proliferation of renal tubular epithelial cells and inhibit EMT, ultimately preventing renal fibrosis in DN [20].