CDKN2A and lung cancer: For instance, Nie et al. revealed the promoting effect of lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) on cell proliferation and the inhibitory effect of ANRIL on apoptosis in lung cancer cells, and the functions might be achieved through silencing of Kruppel-like factor 2 (KLF2) and P21 expression (22).