RHPN2 and neoplasm: The activated receptor EGFR then triggers the TF Androgen Receptor (AR) through protein PCK1 and TF MYC through cascade proteins RHPN2, MTOR, and EIF4B in the corresponding signaling pathways, to regulate proliferation through the mediation of proliferation-related gene EIF4B. However, the secretion of the hydrogen peroxide by nearby cancer cells and cancer-associated fibroblasts (CAFs) could cause the DNA damage, inflammation to the altered tumor microenvironment, and cancer metabolism [131–135].