MDM4 and cancer: In early stage LADC, NOTCH1 is activated by the interaction with ligand Jagged 2 (JAG2) secreted by the nearby cancer cells and triggers TF ETS1 mediated by protein MDM4 and TF ZEB1 mediated by proteins, SLC6A20 and CDC42EP1 in the corresponding signaling pathways to regulate cell migration through the mediation of cell migration-related genes, MYH9 and miR-27b, to regulate ECM remodeling through the mediation of gene LOX, to regulate EMT through the mediation of LOX and ZEB1, and to regulate angiogenesis and apoptosis through the mediation of gene miR-27b.