The receptor DDR1 is activated by collagen COL3A1 to directly trigger the TF YBX1 to regulate DNA repair by the mediation of DNA repair-related gene, ERCC1 and to regulate proliferation by the mediation of proliferation-related gene, SP1. In addition, receptor FGFR1 activated by the ligand FGF2 which may be secreted via nearby fibroblast is involved in cancer growth and malignant progression of NSCLC [65]. This evidence concerns the gene COL3A1 and cancer.