The activated EMR2 then triggers TF FOXL1 through cascade proteins CHD3 and AGR3 in the signaling pathway, to regulate proliferation and cell mobility through the mediation of NF1. The DEAD-box-protein DDX5, an ATP-dependent RNA helicase, has been involved in the promotion of proliferation and tumorigenesis in NSCLC [153]. The gene discussed is AGR3; the disease is non-small cell lung carcinoma.