Though immune response is activated during infection, our results indicate TGFβ1 is secreted by cancer cells in early stage LADC (Figure 2) and plays a role in immunosuppression in lung cancer microenvironment [44–47], suggesting the cancer cells of LADC can prevent cytotoxic attack from lymphocytes, which are recruited to tumor microenvironment through stimulation of inflammation, by secretion of TGFβ1 in cancer microenvironment. The gene discussed is TGFB1; the disease is cancer.