In the normal stage of lung cells near LSCC cancer cells, receptor FGFR1 activated by FGF19, which might be secreted by nearby cancer cells, triggers the repair signaling to affect TF YBX1 through cascade proteins, RPL30 and KLF12 to regulate DNA repair by the mediation of DNA repair-related gene ERCC1. FGF19 participates in a variety of cellular processes, such as tissue repair, cell growth, morphogenesis, and, tumor growth. This evidence concerns the gene ERCC1 and cancer.