In advanced stage LADC, the ESCO1-induced acetylation of ZEB1 leads to the activation of proliferation, gluconeogenesis, cell migration, and extracellular proteolysis through the upregulation of proliferation-related gene EIF4B, extracellular proteolysis-related gene PLAU, gluconeogenesis-related gene PCK1, and migration-related gene CDH2, indicating that these activated cellular functions caused by the acetylation of ZEB1 can promote LADC cancer cells invasion and metastasis. The gene discussed is ESCO1; the disease is cancer.