In early stage, the focal adhesion molecule tensin 1 (TNS1) interacts with the extracellular matrix protein COL1A1, which is a collagen to trigger the TFs JUN, GATA2, and ETS1 via cascade proteins ACTA2, CDKN2A, and PCDP1 in the corresponding signaling pathway and to regulate both the proliferation through the mediation of proliferation-related genes miR-21, miR-106b, and IGF1 and the lymphangiogenesis through the mediation of gene IGF1. In previous microarray analyses, the upregulated COL1A1 was found in various malignant tissues, including lung cancer [109]. The gene discussed is ACTA2; the disease is lung cancer.