Inhibition of ANGPT2 and the subsequent activation of TIE-2 by the ANG2 Binding TIE-2 Activating Antibody (ABTAA) improves vascular stabilization and drug delivery in mouse models of orthotopic glioma, subcutaneous Lewis lung carcinoma and spontaneous mammary cancer [50]. Here, TEK is linked to Carcinoma, Lewis Lung.