Eight were variants that were already detectable in primary O2005: the missense variants in ATP7B (NM_000053:c.1829C>T; allele frequency, AF 3%); C3orf15 (NM_033364:c.1820G>A; AF, 10%); DUSP11 (NM_003584:c.575A>G; AF, 10%); EPHA1 (NM_005232:c.1262C>A; AF 10%); NDST4 (NM_022569:c.2392C>G; AF 20%); SYPL2 (NM_001040709:c.392C>G; AF 20%) and the frame shift mutations in NUP210L (NM_207308:c. Here, NDST4 is linked to atrial fibrillation.