Although the primary oligodendroglioma exhibited 1p/19q codeletion, the variants detected did not include changes in FUBP1 and CIC. Only a few variants, in addition to IDH1 R132H and TERT C250T, were observed in the primary tumor that gained predominance and might represent interesting candidate genes for oligodendroglioma development. The gene discussed is CIC; the disease is oligodendroglioma.