The remaining two variants initially appeared in recurrent O2010 and became predominant in xenograft1: ZAK (NM_016653:c.1618C>T; p.Gln540*; AF 20%; Figure 3) and the InDel in KPNA1 (NM_002264:c.179_181delAAG; p.lu60del; AF 20%). This evidence concerns the gene KPNA1 and atrial fibrillation.