In high-fat diet fed mice, procyanidin extract caused a suppression of hyperglycemia and fat accumulation in adipose tissue (Yamashita, Okabe, Natsume, & Ashida, 2012), while in rats bred for innate low running capacity, chronic treatment with (−)-epicatechin resulted in increased muscle capillarity as well as increased protein expression of mitochondrial biogenesis proteins (PGC-1α and TFAM) (Hüttemann et al., 2013). Here, PPARGC1A is linked to Hyperglycemia.