CYP19A1 and polycystic ovary syndrome: Moreover, Bardei [50] demonstrated that rasp berry fruit extract induced a significant reduction in testosterone level and restored ovarian function in PCOS rats, due to its antioxidant potential. Vitex agnus-castus fruit extract also exhibited an antiandrogenic effect in PCOS rats by increasing aromatase process (increasing the conversion of testosterone into estradiol) leading to low testosterone level [51].