Recently, it has been shown that apigenin potently and significantly reduces cell proliferation of human glioblastoma cell lines through inducing the apoptosis and inhibition of AKT/mTOR signaling pathways (Coelho et al., 2016[22]; Kim et al., 2016[33]; Stump et al., 2017[54]). This evidence concerns the gene MTOR and glioblastoma.