We therefore wanted to reaffirm whether, among the many noncanonical TGF-β signaling pathways, activation of Stat3 by knockdown of PrdxV is one of the signaling pathways of renal fibrosis induced by UUO, and if so, whether any upstream molecules are involved in the activation of Stat3. The gene discussed is TGFB1; the disease is renal fibrosis.