We further explored whether CSF AD biomarker levels in HAND were influenced by viral load and altered levels of key CSF cytokines linked to innate immunity or T-cell-related pathways (selected for biological function and reproducibility in CSF assays), including interferon-γ-inducible protein 10 (CXCL10/IP10), interleukin 8 (CXCL8/IL-8), fractalkine (CX3CL1), tumor necrosis factor alpha (TNF-α), macrophage-derived chemokine (MDC), and interleukin 10 (IL-10). The gene discussed is TNF; the disease is Alzheimer disease.