ITGAX and colorectal carcinoma: However, immunohistochemistry (IHC) double staining demonstrated that a large portion of DC-SIGN-positive cells costained with cytokine 20 or CD11c, which are the two markers of CRC cell and DCs, respectively, indicating that DC-SIGN does not only express on infiltrated DCs of mesenchyme but also on CRC cells (Fig. 1e).