While rpom-1 downregulation caused tumor formation in the germline syncytium of wild-type animals (Fig. 3a, b), it differentially affected daf-2(e1370)/IGFR mutants by producing dwarf gonads at permissive temperatures (20 °C) and aggravating their proliferative defects (Fig. 3c, d). Here, IGF1R is linked to neoplasm.