When cocultured with the NK-92-resistant (MDA-MB-231, SKBR3, HCC1954, T47D, BT20, BT474 and HCC1500) or the less sensitive (MCF-7) breast cancer cells, target-induced NK-92 degranulation was very low (≤3.5-fold increase in CD107a surface expression) (Fig. 2A,B). The gene discussed is LAMP1; the disease is breast cancer.