These findings suggest that the NK-92-sensitive hTERT-immortalized epithelial cells (hTERT-HME1) and cancer cells (BT549) of mammary origin as for the K562 leukemic cells are more potent in inducing NK-92 cell degranulation compared to the relatively more resistant breast cancer cells, which can be the consequence of an increased NK recognition and activation by these target cells. This evidence concerns the gene SFN and breast carcinoma.