CIITA and neoplasm: Consistent with immune recognition of the tumor, highly expressed genes included immune-related genes, such as Granzyme B/K associated with cytolytic function, T-cell markers (CD2, CD3D, CD3E, IL2RG), chemokines/chemoattractants (CXCL9, CXCR6, CXCL10), genes involved in antigen presentation (CIITA, H2-T23, and H2-EA-PS) and immunomodulatory molecules such as IDO and LAG3, the last two factors likely being upregulated as a consequence of T-cell activation and IFN-γ signaling to restrain the antitumor immune responses.