Moreover, we showed that 5-FU treatment induced an increase of p-JNK in splenic CD11b+ Gr-1+ MDSC, obtained from EL4 tumor-bearing mice fed a control diet, whereas DHA-enriched diet significantly reduced 5-FU-induced p-JNK level in these cells (Fig. 2e and Fig. S2e). Here, MAPK8 is linked to neoplasm.