Most importantly, this Ro signature enriched for the gene expression profiling after shRNA mediated depletion of MSI2 in CML-BC (AR-230 and LAMA84) and AML cell lines (THP1 and NOMO-1) (Fig. 5c and Supplementary Data 5)27. This evidence concerns the gene MSI2 and chronic myelogenous leukemia, BCR-ABL1 positive.