When transitioned relatives were compared to either non-transitioned relatives or controls, the association between VCA IgG levels and transitioning to SLE was modified by SLE-associated SNPs in CD40 rs4810485 and VCA IgA levels were associated with increased risk of transitioning in individuals with 0 minor alleles at IL10 rs3024493. Here, CD79A is linked to systemic lupus erythematosus.