Increasing levels of VCA IgG and EA IgG were associated with transitioning to SLE when compared to controls (Table 2), and the association remained after additional adjustment for ANA positivity (OR 1.46, 95%CI 1.09–1.97, p=0.01 and OR 2.00 95%CI 1.21–3.31, p=0.007, respectively). The gene discussed is BTG3; the disease is systemic lupus erythematosus.