CALR and systemic lupus erythematosus: Aberrant antibody responses against Epstein-Barr Nuclear Antigen-1 (EBNA-1) can incite antibody responses against lupus autoantigens, Sm and Ro.[30 ,31] Anti-Ro responses were shown to be among the first autoantibodies detected preceding SLE classification in longitudinal samples.[32] In this study, we show that the transitioned relatives had increased VCA IgG and EA IgG responses compared to non-transitioned relatives who were ANA negative at baseline.