Besides, the oncolytic virus activates the sequestosome 1(SQSTM1/p62)-mediated autophagic machinery to reduce the mitochondrion-tethered mitochondrial antiviral signaling protein (mitophagy) and then abrogates the innate immune response in nonsmall cell lung cancer (NSCLC) cells which results in enhancement of viral propagation. The gene discussed is SQSTM1; the disease is lung cancer.