Peripheral pro-inflammatory IL-1β was significantly elevated pre-L4 DRGSTIM, but not post-L4 DRGSTIM, while anti-inflammatory IL-10 also declined after 3 months of unilateral L4-DRGSTIM with oxytocin from saliva increased after 3 months L4-DRGSTIM. Members of the adipokine superfamily associated with metabolic disorders such as ghrelin and adiponectin remained unchanged [1]. Here, IL1B is linked to metabolic disease.