When adjusted for age, sex, education, BMI, ApoE e4 allele and Amyloid-PET imaging, and additionally adjusted for disease history including diabetes hyperlipidemia, heart disease, hypertension, stoke, traumatic brain injury, the ORs of cognitive impairment in the upper range group compared with the lower range group were similar to those of the unadjusted model (OR = 4.8, 95% CI 1.3–17.9; OR = 5.6, 95% CI 1.4–22.9, respectively).. Here, APOE is linked to hypertensive disorder.