With a median follow-up of 27.9 months (range, 10 to 95 months), patients with high TOP2A expression showed significantly poorer cancer-specific survival (CSS, Fig. 2d, median, 21.3 vs. 41.1 months, P = 0.004), progression-free survival (PFS, Fig. 2e, median, 16.8 vs. 33.6 months, P = 0.008) and recurrence-free survival (RFS, Fig. 2f, 11.6 vs. 37.3 months, P = 0.004) compared with patients with low TOP2A expression. This evidence concerns the gene TOP2A and cancer.