The TOP2A staining score was also significantly higher in high-grade tumor (1.67 ± 0.74) and MIBC tumor (1.56 ± 0.49) than low- grade tumor (1.11 ± 0.43, P < 0.001) and NMIBC tumor (1.27 ± 0.45, P < 0.001), respectively. This evidence concerns the gene TOP2A and neoplasm.