CXCR3 and neoplasm: However, the dual activity of CXCR3-A in the proliferative loops and the attraction of immune cells to the tumor bed, and the opposing roles of the CXCR3 variants’ ligand–receptor axis, as well as ligand and cell context bias, are important aspects that need to be considered for the development and use of anti-CXCR3 drugs or neutralizing antibodies.