For example, CXCL9 and CXCL10 induce effector Th1/Th17 cells and CXCL11 drives a Treg and Th2-biased effector cell polarization upon activation of CXCR3 on CD4+ T cells, while they upregulate tumor cell-related proteins that are beneficial for their survival, such as PD-L1 [21,101,102]. This evidence concerns the gene CD4 and neoplasm.