Indeed, by upregulating the expression of CXCR3-A and lowering the expression of CXCR3-B at their surface, tumor-initiating cells are able to enhance their proliferative potential and survival through autocrine stimulation loops that are further reinforced by the simultaneous upregulation of the expression of the CXCR3 ligands in the TME. The gene discussed is CXCR3; the disease is neoplasm.