Similarly, in a B16 melanoma mouse model, the deletion of CXCR3 in CTLs lead to an impaired anti-tumoral response due to the failure of CTL infiltration in the TME upon anti-PD-1 treatment, suggesting CXCR3-dependent anti-PD-1 based anti-tumoral response [46]. This evidence concerns the gene CXCR3 and melanoma.