Due to the high expression of CXCR3-B on endothelial cells and the angiostatic effect of CXCL10, CXCL9, and CXCL4 [24,87,88,89,90], it was proposed that the CXCR3-B variant could be responsible for this negative impact on tumor angiogenesis. This evidence concerns the gene CXCL10 and neoplasm.