Therefore, a better understanding of all aspects of the biology of CXCR3 variants, including their exact signaling pathways and cellular responses in the tumor-microenvironment context, is urgently needed before envisaging the CXCR3 variants as potential anti-tumoral targets and the development of CXCR3 variant-specific drugs to be used for combined therapy, for example with anti-PD-1 immunotherapy, to turn cold to hot tumors. This evidence concerns the gene CXCR3 and neoplasm.