Vanderver et al. reported the brain MRI findings (including enlarged perivascular spaces and multifocal periventricular white matter abnormalities) in a cohort of 23 patients with PTEN mutations and macrocephaly [63], while Ciaccio et al. found various brain abnormalities in 75% of pediatric PTEN mutation carriers who had imaging [64] and Hansen-Kiss et al. found a range of abnormalities in 53% of 17 children with PTEN mutations who had brain imaging [62]. This evidence concerns the gene PTEN and Macrocephaly.