Mast cells activated by IgE cross-linkage release various chemical mediators by degranulation, among which CysLTs such as LTC4, D4, and E4 are thought to play a role in asthma pathophysiology by inducing bronchoconstriction, mucus secretion, inflammatory cell recruitment and activation, fibrosis, and pulmonary edema formation. The gene discussed is IGHE; the disease is asthma.