AGT and hypertensive disorder: Mice deficient for HO-2 do not exhibit enhanced blood pressure response to Ang II-dependent or N(ω)-nitro-L-arginine methyl ester (L-NAME)-dependent hypertension; however, HO-2 knockout mice do exhibit a sex difference in response to renovascular hypertension with male knockout mice exhibiting an exaggerated blood pressure response as compared to wild-type mice and female knockout mice lacking any difference to wild-type mice [34,35].