The researchers generated the anti-MMP-9 antibody CALY-001 and evaluated its efficacy in a mouse model of intestinal fibrosis in comparison to AB-0046-h4, a potent and selective allosteric mouse monoclonal antibody against MMP-9 that reduced disease severity in a dextran sodium sulfate-induced mouse model of ulcerative colitis [104]. Here, MMP9 is linked to ulcerative colitis.