Further in vivo studies of murine breast tumor models showed that MMP-14 blockade by DX-2400 decreased immunosuppressive TGFβ, polarized macrophages to an antitumor phenotype, increased inducible nitric oxide synthase, and improved tumor perfusion, resulting in reduced primary tumor growth and enhanced response to radiation therapy, especially in high MMP-14 expressing tumors [107]. Here, NOS2 is linked to neoplasm.