KIT and Splenomegaly: These include, among others, multi-lineage involvement of hematopoietic cells with KIT D816V, the variant allele frequency (VAF) of mutated KIT, an elevated β2-microglobulin, elevated alkaline phosphatase levels, lymphadenopathy and splenomegaly, and the presence of additional somatic mutations (Table 4) [22,23,24,25,37,38,39,49,50,51].