PGF and neoplasm: After all, PlGF is able to upregulate the expression of additional angiogenic factors such as VEGF, basic fibroblast growth factor (FGF-2), platelet-derived growth factor β (PDGF-β), and matrix metalloproteinases (MMPs), among other molecules, by periendothelial fibroblasts, smooth muscle cells, or inflammatory cells in wound or tumor stroma as well [106,107].