Again, although the VEGFR1 signaling does not affect the proliferation of T lymphocytes, the engagement of VEGFR1 on activated T cells induces such cells both to migrate towards the tumor site and to increase locally IL-10 production, indicating that VEGFR1 is able to mediate a direct immunomodulatory effect on T cells [122]. The gene discussed is IL10; the disease is neoplasm.