TNF and neoplasm: An additional link between inflammation and PlGF has been provided with the demonstration that TNF-α is upregulated by tumor-derived PlGF in myelomonocytic cells via the transcription factor Nuclear Factor of Activated T cells-1 (NFAT-1), which in turn contributes to PlGF-induced myelomonocytic cell recruitment [91], thus establishing a vicious circle that feeds tumor-associated inflammation.