ERBB2 and breast carcinoma: Among the high penetrance genes, p53 has a significant role in the malignancy of breast cancer with it mutations were more frequently observed in 30% of the breast carcinomas of which 26% are in luminal tumors (17% of luminal A, 41% of luminal B), 50% are in HER2 amplified tumors, 69% are in molecular apocrine breast carcinomas and 88% are in basal-like carcinomas [37].