Autophagy is a degradation process of cytoplasmic components mediated by lysosomes, involving four shared PCOSrps (AKT1, RB1CC1 (RB1-inducible coiled-coil protein 1), GABARAP (gamma-aminobutyric acid receptor-associated protein), and SNAP29 (synaptosomal-associated protein 29)) with schizophrenia, three shared PCOSrps (AKT1, HIF1A (hypoxia-inducible factor 1-alpha), and PRKACA (cAMP-dependent protein kinase catalytic subunit alpha)) with depressive disorder, and one shared PCOrp (AKT1) with obesity. The gene discussed is AKT1; the disease is depressive disorder.