Importantly, in addition to schizophrenia-related behavioral phenotypes, such as impaired PPI, ASD-related behavioral phenotypes, such as social dysfunction and increased repetitive self-grooming behavior, and impaired fear learning, Df/+ mice also showed growth defects and microcephaly, which are reminiscent of the phenotypes in patients with 3q29 deletion syndrome. The gene discussed is CFD; the disease is Down syndrome.