TRPM8 and cancer: TRPM8 has been implicated in a plethora of pathological conditions and diseases, including pain (Colburn et al., 2007, De Caro et al., 2018, Dhaka et al., 2007, Knowlton et al., 2013, Liu et al., 2013, Proudfoot et al., 2006), inflammation (Caceres et al., 2017, Ramachandran et al., 2013, Wang et al., 2017), itch (Palkar et al., 2018), thermoregulation and energy metabolism (Li et al., 2018, Reimúndez et al., 2018), cancer (Yee, 2015), dry eye diseases (Yang et al., 2018), and airway diseases (Liu et al., 2018).