However, the current PET ligands lack demonstration of selectivity between Tau and TDP43 pathology, despite being sensitive to the burden and distribution of Tau pathology in FTD, progressive supranuclear palsy and Alzheimer’s disease (Bevan-Jones et al. 2017; Passamonti et al. 2017). This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.