Immunohistochemical analysis for p53 protein expression was done for 15 cases with available blocks; these included 3 cases with structural variants (all metastatic carcinomas), 3 with pathogenic missense variants (1 primary, 2 metastatic carcinomas), and 9 with no detectable TP53 alterations (4 primary, 5 metastatic carcinomas). This evidence concerns the gene TP53 and metastatic carcinoma.