Questions still unanswered include: (1) What roles does p73 play in epidermal and HF stem cells after injury and how do they differ between the cell types?; (2) What is the relative contribution of p73 isoforms to the wound healing phenotypes observed in p73-/- mice?; and (3) Does p73 have any roles in stem cell maintenance in the skin, similar to p63 [1,76]? The gene discussed is TP63; the disease is hydrops fetalis.