Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, a rare ectodermal dysplasia caused by heterozygous mutations in the C-terminus of TP63, is distinguished from other human TP63-associated disorders by the occurrence of severe skin erosions, especially those of the scalp [78,79]. The gene discussed is TP63; the disease is ectodermal dysplasia syndrome.