There is a high volume of recent FA research that uses DNAm: Martino et al. 2018 [15] used integrated DNAm and transcriptome profiling to conclude that the activation of naive CD4+ T cells results in poorer lymphoproliferative responses in children with FA, Sicherer and Sampson 2018 [16] suggest the use of DNAm signatures to create FA-related diagnostic tests, and Song et al. 2017 [17] state that DNAm regulates genes that are critical for the development of FA. Here, CD4 is linked to Friedreich ataxia.