FH and gonorrhea: To ensure activity of mAb 2C7 in the context of chlamydia coinfection, we administered mAb 2C7-E430G Fc to FH/C4BP Tg mice coinfected with FA1090 and C. muridarum. As shown in Fig 9, 2C7-E430G Fc given intravaginally at a dose of 1 μg daily significantly reduced the duration and burden of gonorrhea in coinfected mice.