This gene signature includes WNT10A, JUNB, FOSL2, MYCN, TNFAIP3, KLF4 and EDN1 with HR>1 (high expression correlates with HCC development) and PCSK9 with HR<1 (low expression correlates with HCC development). The gene discussed is TNFAIP3; the disease is hepatocellular carcinoma.