The level of the epigenetic marker at the position of genes WNT10A, JUNB, FOSL2, TNFAIP3, KLF4 and EDN1 was increased, and decreased at the position of genes MYCN and PCSK9 (Fig 4C), as was demonstrated by using the in vitro HCV-infection systems (Fig 2E and 2F). Here, EDN1 is linked to infection.