CACNA1C and major depressive disorder: Besides, literature has identified Cav1.2 and Cav1.3 channels as specific molecular and cellular cascades that underlie mood (anxiety and depression), social behavior, and cognition in rodents (Mogilnicka et al., 1987; Bader et al., 2011; Kabir et al., 2016, 2017) As well, interesting data demonstrated that the BACHD mouse recaps clinical HD with early psychiatric aspects, such as depressive and anxiety-like features (Hult Lundh et al., 2013).