Notably, L-type Ca2+ channel blockers were also found to have neuroprotective effects against Aβ-induced neuronal apoptosis in cultured rat cortical neurons (Yagami et al., 2004) and from amyloid precursor protein (APP)-induced neurotoxicity in neuroblastoma cells (Anekonda and Quinn, 2011). The gene discussed is APP; the disease is neuroblastoma.