PARK7 and Parkinson disease: To develop a more physiologically relevant cellular model of PD, in this study we established H2O2 induced L166P and C106S DJ‐1‐transfected SH‐SY5Y cells, and investigated the effects of Cistanche extracts and key bioactive compounds, including acteoside, echinacoside, caffeic acid, and Cistanche total glycosides on these two models, for the first time.