We analyzed a total of 111 mutations, finding cosmic mutations in NRAS, PTEN, KRAS, IDH2, STK11, ERBB4, VHL, PIK3CA, APC, SMO, and NOTCH1 genes uniquely present in all sequential generations of CDX‐derived liver tissue (Table 1 and Fig. S2); of note, PIK3CA gene cosmic mutation (COSM21451) is known to be associated with HCC (Forbes et al., 2017). The gene discussed is IDH2; the disease is hepatocellular carcinoma.