Transfection of the master transcriptional activator of class II (CIITA) into poorly immunogenic class II-negative adenocarcinoma cell lines resulted in these cells developing robust antigen-processing function, with massive infiltration by both CD4+ and CD8+ T cells, and tumour rejection occurred when the CIITA-transfected cell lines were infused into mice66,.67 This evidence concerns the gene CIITA and adenocarcinoma.