Genes at 8q24.3 that may be considered promising candidates on the basis of their degrees in the biclusters include PUF60, EXOSC4, COMMD5, and HSF1. Specifically, PUF60 is an RNA-binding protein known to contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis [51]. This evidence concerns the gene EXOSC4 and neoplasm.