In a recent study, the appearance of a subset of γδ T lymphocytes bearing αEβ7 in the mesenteric lymph node and intestine was reported to precede the development of colitis in the SAMP mouse model of ileitis.75 In this study, a distinct subpopulation of αEβ7+α4β7high γδ exacerbated Th1/Th17 T‐lymphocyte accumulation in colonic tissue and disease when transferred with CD4+ T cells to immunodeficient RAG mice. This evidence concerns the gene CD4 and colitis.