PGP and neoplasm: In our study, by using the activators and inhibitors of EGFR/ERK/Akt/NF-κB signaling pathway as well as overexpression or knockdown of key signaling molecules, we demonstrated that IVM downregulated the expression of P-gp at least largely through inhibiting the activation of the EGFR/ERK/Akt/NF-κB pathway in tumor cells.