Moreover, the cells with positive staining of CD13 or CD33, the surface markers of K562 cells, as well as the mRNA levels of bcr/abl fusion gene, a marker of chronic myeloid leukemia, in peripheral blood and bone marrow of IVM plus ADR-treated mice were lower than that in the ADR alone-treated mice (Fig. 3f; Additional file 1: Figure S2C & D). Here, CD33 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.